MRCPUK SEND : Endocrinology and Diabetes (Specialty Certificate Examination)

  • Exam Code: SEND
  • Exam Name: Endocrinology and Diabetes (Specialty Certificate Examination)
  • Updated: Aug 01, 2026
  • Q & A: 200 Questions and Answers

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MRCPUK SEND Exam Syllabus Topics:

SectionObjectives
Topic 1: Endocrine Emergencies- Diabetic ketoacidosis and hyperosmolar states
- Thyroid and adrenal crisis
Topic 2: Pituitary and Hypothalamic Disorders- Diabetes insipidus and SIADH
- Pituitary adenomas and hypopituitarism
Topic 3: Diabetes Mellitus- Type 1 and Type 2 diabetes management
- Diabetic complications and emergencies
Topic 4: Thyroid Disease- Thyroid nodules and cancer
- Hyperthyroidism and hypothyroidism
Topic 5: Adrenal Disorders- Addison disease and adrenal insufficiency
- Cushing syndrome
Topic 6: Calcium, Bone and Metabolic Disease- Calcium and vitamin D disorders
- Osteoporosis and metabolic bone disease
Topic 7: Metabolic Disorders- Lipid disorders
- Obesity management
Topic 8: Neuroendocrine Tumours and Multiple Endocrine Neoplasia- MEN syndromes
- Carcinoid and pancreatic NETs
Topic 9: Reproductive Endocrinology- Polycystic ovary syndrome (PCOS)
- Hypogonadism and infertility

MRCPUK Endocrinology and Diabetes (Specialty Certificate Examination) Sample Questions:

1. A 50-year-old woman with acromegaly presented with persistent sweating and headaches
despite having undergone trans-sphenoidal surgery and pituitary radiotherapy 2 years
previously. She had been intolerant of treatment with octreotide.
Investigations:
serum growth hormone11.1 ?g/L (<0.4)
serum insulin-like growth factor 186.2 nmol/L (5.6-23.3)
Following imaging, it was judged that there was no role for repeat surgery. She was treated
with pegvisomant 10 mg. Six months into treatment, her symptoms had improved.
Investigations (6 months later):
serum growth hormone20.3 ?g/L (<0.4)
serum insulin-like growth factor 115.2 nmol/L (5.6-23.3)
What is the most appropriate next step in management?

A) increase dosage of pegvisomant
B) arrange another full course of pituitary radiotherapy
C) continue present dosage of pegvisomant
D) add cabergoline
E) stop pegvisomant


2. A 45-year-old woman was found to be hypertensive by her general practitioner. She was otherwise well and was not taking any medication. However, she regularly ate health food containing liquorice. There was no family history of significant illness.
On examination, her blood pressure was 170/110 mmHg.
Investigations:
serum sodium140 mmol/L (137-144)
serum potassium3.8 mmol/L (3.5-4.9)
serum creatinine70 umol/L (60-110)
plasma renin activity (after 30 min supine)0.5 pmol/mL/h (1.1-2.7)
plasma aldosterone (after 30 min supine)450 pmol/L (135-400)
During the investigations, her blood pressure was controlled with doxazosin. What is the most likely diagnosis?

A) Gitelman's syndrome
B) apparent mineralocorticoid excess
C) pseudohyperaldosteronism
D) renal artery stenosis
E) primary hyperaldosteronism


3. A 37-year-old woman was seen in clinic with a 2-month history of mild galactorrhoea. She had a long-standing history of hypothyroidism, treated with levothyroxine 125 micrograms daily, and a history of mental health issues, treated with risperidone. Her menstrual cycle was regular.
An MR scan of brain, requested elsewhere as part of a workup for headaches and other somatic symptoms, was available.
Investigations:
serum prolactin3000 mU/L (<360)
serum thyroid-stimulating hormone4.8 mU/L (0.4-5.0)
serum free T411.0 pmol/L (10.0-22.0)
MR scan of brainno abnormalities reported
What is the most appropriate next step in the management of her hyperprolactinaemia?

A) reassurance of no significant pituitary pathology
B) add cabergoline
C) MR scan of pituitary fossa
D) increase levothyroxine dosage
E) stop risperidone


4. A 72-year-old woman presented with a painless swelling in the front of the neck, which she had first noticed 2-3 months previously. She was otherwise well, with no symptoms of mass effect in her neck, and was not taking any medication.
On examination, her thyroid gland was moderately enlarged, and felt uniformly nodular. There was no associated lymphadenopathy. Her pulse was 78 beats per minute and regular, and there were no signs of thyrotoxicosis.
Investigations:
serum thyroid-stimulating hormone<0.01 mU/L (0.4-5.0)
serum free T424.8 pmol/L (10.0-22.0)
serum free T310.3 pmol/L (3.0-7.0)
technetium-99m scan of thyroid (20-min uptake)patchy uptake in both thyroid lobes
What is the most appropriate management?

A) carbimazole plus levothyroxine
B) partial thyroidectomy
C) total thyroidectomy
D) radioiodine
E) repeat thyroid function tests after 6 months


5. A 28-year-old man was seen in the lipid clinic following a referral from the general surgical team. He had had two episodes of acute pancreatitis over the preceding 6 months, which settled spontaneously. He had a past medical history of HIV disease and was taking highly active antiretroviral (HAART) therapy. He drank 12 units of alcohol per week.
On examination, he had no stigmata of hyperlipidaemia.
Investigations:
fasting plasma glucose6.2 mmol/L (3.0-6.0)
haemoglobin A1c44 mmol/mol (20-42)
serum cholesterol7.5 mmol/L (<5.2)
fasting serum triglycerides23.70 mmol/L (0.45-1.69)
serum thyroid-stimulating hormone0.7 mU/L (0.4-5.0)
serum free T414.3 pmol/L (10.0-22.0)
What class of antiretroviral drug is the most likely cause of his metabolic disturbance?

A) nucleoside reverse transcriptase inhibitors (e.g. zidovudine)
B) protease inhibitors (e.g. ritonavir)
C) integrase inhibitors (e.g. raltegravir)
D) entry inhibitors (e.g. enfuvirtide)
E) non-nucleoside reverse transcriptase inhibitors (e.g. nevirapine)


Solutions:

Question # 1
Answer: C
Question # 2
Answer: E
Question # 3
Answer: A
Question # 4
Answer: D
Question # 5
Answer: B

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