USMLE United States Medical Licensing Examination : USMLE

  • Exam Code: USMLE
  • Exam Name: United States Medical Licensing Examination
  • Updated: Aug 06, 2026
  • Q & A: 400 Questions and Answers

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About USMLE United States Medical Licensing Examination : USMLE Exam

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USMLE USMLE Exam Syllabus Topics:

TopicDetails
Topic 1
  • Infectious and inflammatory disorders of the eye
  • Adverse effects of drugs on the immune system
Topic 2
  • Deficiency of phagocytic cells and natural killer cells
  • Adverse effects of drugs on the nervous system
Topic 3
  • Biology of tissue response to disease
  • Disorders of balance and spatial orientation
Topic 4
  • Adverse effects of drugs on the hematologic and lymphoreticular systems
  • Disorders associated with immunodeficiency
Topic 5
  • Deficiency primarily of humoral immunity
  • Immunologic and inflammatory disorders
Topic 6
  • Maladaptive behavioral responses to stress and illness
  • Immunologic and inflammatory disorders
Topic 7
  • Adaptive behavioral responses to stress and illness
  • Biochemistry and molecular biology

Reference: http://www.usmle.org/step-1/#question-formats

USMLE Step 3 is open to candidates who already hold their USMLE Step 1 and Step 2 certificates. Step 3 is a two-day exam that assesses whether candidates are able apply medical knowledge and understanding of biomedical and clinical science essential to unsupervised medical practice. This is the final USMLE exam which leads to the license to practice medicine without supervision - the ultimate goal of medical students and professionals willing to practice medicine in the United States. Step 3 represents the final assessment of physicians assuming independent responsibility for delivering general medical care.

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USMLE Step 1 is a one-day (8 hours) examination. It includes 322 multiple-choice questions divided into 7 blocks of 46 items (60 minutes are given for completion of each block).

USMLE Step 2 is a one-day (8 hours) exam. Similar to the Step 1, the test items are divided into blocks, and test item formats vary within each block, with the total number of exam questions equaling to 355.

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